Further, we exposed cells to irradiation and again G55 cells showed a lower sensitivity when DDIT4 was induced, whereas LNT-229-stable DDIT4-overexpressing cells showed only a slight trend for a survival advantage (Fig. 4b ).
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The physiological mTOR complex 1 inhibitor DDIT4 mediates therapy resistance in glioblastoma.
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Values of p > 0.05 were regarded not significant (NS), and values of p < 0.05 significant (*) and values of p < 0.01 highly significant (**).