A minimum of two years of undertreated primary hypothyroidism, as a result of drug-induced malabsorption of l-thyroxine, may have metabolic and cardiovascular consequences.

J Clin Transl Endocrinol · 2019 · PMC6462542 · PMID 31011539

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

0.0510

boldest claim

The sentences

extremely significantP = 2.2 × 10 −20actually significant

Co-ingestion of tablet L-T4 and any interfering drug(s) was associated with serum TSH levels approximately 100% greater than those associated with ingestion of tablet L-T4 alone, the difference being extremely significant (P = 2.2 × 10 −20 ).

also in 7,787 other papers

borderline significantP = 0.051so close (0.05 < p ≤ 0.1)

The exceptions were the significant difference concerning abdominal obesity (31/76 [40.8%] vs 7/38 [18.4%], χ 2 = 5.7, P = 0.017, OR = 3.05 [95% CI 1.2–7.8]) and the borderline significant difference concerning reduced HDL (9/76 [11.8%] vs 10/38 [26.3%], χ 2 = 3.8, P = 0.051, OR = 0.38 [95% CI 0.14–1.0]) [not shown].

also in 11,409 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.