Platelet function testing at low platelet counts: When can you trust your analysis?

21 , 22 Also, in another recent study, it was found that although there was an increased incidence of bleeding events during delivery in women with inherited thrombocytopenia and a platelet count of <50 × 10 9 L −1 , the increased incidence did not seem to be linearly correlated with platelet counts, as the odds ratio (OR) for bleeding events showed a nonsignificant trend towards lower incidences of bleeding in the tertile of platelets with a platelet count of 49‐80 × 10 9 L −1 in comparison with patients with a platelet count of > 80 × 10 9 L −1 . 23 These observations indicate that clinical decision making needs to be based on knowledge regarding both quantitative and qualitative defects in primary hemostasis.

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Our results demonstrate dramatic and highly significant effects of sample platelet count on aggregation responses in the tested platelet count interval (Figures 1 G,H and 2 G,H).

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