Importance of Incorporating Protein Flexibility in Molecule Modeling: A Theoretical Study on Type I<sup>1/2</sup> NIK Inhibitors.

Front Pharmacol · 2019 · PMC6465739 · PMID 31024312

Europe PMC DOI

hedged sentence

—

closest p

—

boldest claim

The sentences

an increasing trendno p-value reported

On account of the addition of 5-methylisoxazole ring, not only above key residues around the back pocket, but also some other adjacent residues (such as Cys446 m and Val455 m ), show an increasing trend in the non-polar contributions, thereby facilitating the high activity of 10 .

also in 63,971 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.