α-Ketoglutaric Acid-Modified Carbonate Apatite Enhances Cellular Uptake and Cytotoxicity of a Raf- Kinase Inhibitor in Breast Cancer Cells through Inhibition of MAPK and PI-3 Kinase Pathways.

An increasing trend of turbidity was noted for α-KAMCA NPs with an increasing concentration of α-ketoglutaric acid, probably due to the increased number of particles and slow enlargement of the particle size ( Figure 1 A). α-KAMCA NPs formulated with different concentrations of alpha-ketoglutaric acid salt were exposed to MCF-7 cell line to evaluate the probable toxic effect of the NPs.

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