an overall trendP < 0.001
As expected from earlier SAR work on this series, 6 , 7 , 8 there was a good overall correlation between the MABA and LORA MIC 90 values for the compounds: (1) l o g MABA = 0.98 ∗ l o g LORA - 0.08 n = 58 , R = 0.85 , p < 0.001 , F 2 , 56 = 144 Also, as expected, there was a reasonable correlation between inhibitory activity (illustrated here for MABA data) and compound lipophilicity, with the more lipophilic compounds being more potent; an overall trend repeatedly seen in other classes of TB drugs. 12 , 13 (2) logMABA = - 0.50 ∗ c l o g P + 1.97 n = 58 , R = 0.71 , P < 0.001 , F 2 , 56 = 55 However, this overall correlation masks a trend seen to some extent previously, 8 that for this general class of compound, MIC 90 potency falls off quite sharply for compounds (e.g., 3 , 8 , 16 , 18 , 23 , 25 , 27 , 29 , 31 , 42 , 44 , 52 ) of lower lipophilicity (clogP values around 4 or below).