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<i>Nigella sativa</i>and its Derivatives as Food Toxicity Protectant Agents.

Adv Pharm Bull · 2019 · PMC6468232 · PMID 31011555

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highly significantno p-value reported
In addition, a highly significant increase in the blood creatinine and pyruvate kinase isoenzyme tumor M2 concentration was observed in TQ and ZEN treated group (T4) compared to control group.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.