Enantioselective Box Behenken Optimized HPLC-DAD Method for the Simultaneous Estimation of Alogliptin Enantiomorphs in Pharmaceutical Formulations and their Pharmacokinetic Study in Rat Plasma.

Adv Pharm Bull · 2019 · PMC6468233 · PMID 31011569

Europe PMC DOI

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may be significantno p-value reported

Till now the stereoselective biotransformation of ALO and their effect on ALO quantities in plasma is not known in published literature. Conclusion There may be significant variability between the enantiomers of chiral drugs in terms of their pharmacokinetics, efficacy, receptor affinity and toxicity.

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