highly significantp < 0,0001
In pilot clinical studies increased levels of Epi were detected in 20% of plasma samples collected from PC patients [ 27 ] and a highly significant positive correlation (0.91; p < 0,0001) was observed between increased blood Epi and the phosphorylation of S133CREB in prostate biopsies [ 58 ], which supports the relevance of preclinical model data to human prostate gland.