The Novel Mnk1/2 Degrader and Apoptosis Inducer VNLG-152 Potently Inhibits TNBC Tumor Growth and Metastasis.

Cancers (Basel) · 2019 · PMC6468747 · PMID 30832411

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highly significantno p-value reported

The novel and highly significant recent serendipitous finding that Mnk1 and Mnk2 regulate mammalian target of rapamycin complex 1 (mTORC1) signaling and associates with mTORC1 directly [ 31 , 32 ] suggest that Mnk1/2 inhibitors/degraders can also inhibit mTORC1/4E-BP1/p70SK6 signaling.

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