Cocaine-Induced Reinstatement of Cocaine Seeking Provokes Changes in the Endocannabinoid and <i>N</i>-Acylethanolamine Levels in Rat Brain Structures.

In the yoked cocaine and yoked saline groups, the difference between pressing the “active” versus the “inactive” lever failed to reach significance both in the experiment used to evaluate the endocannabinoid and NAEs tissue level and in the expression of cannabinoid receptors (a two-way ANOVA for repeated measures: Yoked cocaine + i.p. cocaine: F(24,336) = 0.83; p = 0.69 and F(24,288) = 1.27; p = 0.18; Yoked saline + i.p. cocaine: F(24,336) = 0.59; p = 0.79 and F(24,288) = 0.31; p = 0.99; Yoked saline + i.p. saline: F(24,336) = 0.45; p = 0.83 and F(24,288) = 0.31; p = 0.99, respectively). 2.2.

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