Halogen-Substituted Triazolethioacetamides as a Potent Skeleton for the Development of Metallo-β-Lactamase Inhibitors.

There are two differences between the enzymes which may be significant for the inhibitor binding MβLs: (1) The distance between Zn(II) ion and Asp124 which interacts with the hydroxyl group and the triazole ring of 2 in NDM-1, is bigger in VIM-2 (16.12 Å, PDB code 4NQ2) than in NDM-1 (2.12 Å, PDB code 4EYL).

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