Transcriptome networks identify mechanisms of viral and nonviral asthma exacerbations in children.

In the larger unpaired cohort, each of these modules met a stringent significance threshold of FDR < 0.05; in the smaller paired cohort, they were each borderline significant with FDR values of 0.06 and 0.22 (Supplementary Fig. 4a ).

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Other FDR values that were close to significance are also reported in the text.

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When related to exacerbation probability, an elevated ratio of ‘type 2 inflammation’ to ‘type I IFN response’ expression corresponded to a highly significant risk for exacerbation in the short term, with individuals in the highest quartile having a significantly shorter time to exacerbation than individuals in the lower three quartiles ( P < 0.001) and >50% risk of an exacerbation in the first 30 d after the baseline visit (Fig. 5a ).

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