The Promoter Regions of Intellectual Disability-Associated Genes Are Uniquely Enriched in LTR Sequences of the MER41 Primate-Specific Endogenous Retrovirus: An Evolutionary Connection Between Immunity and Cognition.

Interestingly, when performing enrichment analyses of the list of genes encoding such 80 proteins ( Supplementary Table 7 ), we found a highly significant enrichment in genes that are either associated with immune-related terms, as identified by text mining (“immune System”, “NFKB complex”, “arthritis” and others), or linked to immune biological processes according to the GO term classification (“cellular response to IL-21,” “cellular response to IL-2” and others).

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