SIRT3 mediates hippocampal synaptic adaptations to intermittent fasting and ameliorates deficits in APP mutant mice.

To understand whether SIRT3 is also involved in the adaptive responses of neuronal network activity to IF, we performed immunoblot analysis of SIRT3 protein levels in hippocampal tissues and found that 24 h of FD in AL control mice had no effect on SIRT3 levels, and that mice maintained on IF for 1 month exhibited a highly significant elevation of SIRT3 levels (Fig. 2a ).

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