Excessive miR-25-3p maturation via N⁶-methyladenosine stimulated by cigarette smoke promotes pancreatic cancer progression.

Notably, a highly significant enrichment of RGAC motifs at NKAP-binding footprints (CIMS or CITS along with a 5-nucleotide flanking sequence) was identified by iCLIP-sequencing ( P < 10 −12 , Wilcoxon rank-sum test, Fig. 5g ), suggesting that NKAP preferentially binds the m 6 A core motif RGAC.

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