Electrophysiological and Pharmacological Characterization of Human Inwardly Rectifying K_ir2.1 Channels on an Automated Patch-Clamp Platform.

Linear regression of these data as a function of log [K + ] out yielded a highly significant ( r 2 = 0.992) fit ( Fig. 2 , inset) with an estimated 54 ± 3.4 mV shift of the zero-current potential per tenfold variation of external [K + ] out , in good agreement with the Nernst equation prediction of 58 mV per decade.

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