Maintenance of epigenetic landscape requires CIZ1 and is corrupted in differentiated fibroblasts in long-term culture.

GSEA with these CIZ1-dependent transcription units also revealed highly significant overlap with genes regulated by PRC1 and PRC2 (Fig. 3a , Supplementary data 2 , tab 1 ), though unlike culture-adapted cells there was little change in PRC subunit transcript levels (Supplementary Fig. 2 ), and also no gross change in the overall immuno-staining pattern for SUZ12, RING1B or BMI1 in primary cells (Supplementary Fig. 2 ).

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