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HC diet inhibited testosterone synthesis by activating endoplasmic reticulum stress in testicular Leydig cells.

J Cell Mol Med · 2019 · PMC6484377 · PMID 30884106

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a decreasing trendno p-value reported
At the 4th, 8th and 12th weeks, the serum testosterone levels showed a decreasing trend in the rats treated with the cholesterol diet.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.