11 , 12 , 13 , 14 The interventions in the SEARCH and HPS2-THRIVE studies did not result in statistically significant reductions in their primary vascular outcomes, but statin therapy in the HPS study resulted in a highly significant 24% proportional reduction in the incidence of major vascular events.
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Assessment of Vascular Event Prevention and Cognitive Function Among Older Adults With Preexisting Vascular Disease or Diabetes: A Secondary Analysis of 3 Randomized Clinical Trials.
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