Posthoc comparisons found the most pronounced differences at hour 19 when Shank3 ΔC mice spent more time in wakefulness (p<0.0001) and less time NREM (p<0.0001) and REM (p=0.040) sleep ( Figure 2A ) marking the beginning of an overall trend for increased wakefulness during the last half of the dark period.
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Shank3 modulates sleep and expression of circadian transcription factors.
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