Cortical circuit alterations precede motor impairments in Huntington's disease mice.

Analysis of the Pearson’s correlation coefficient (r) for neuronal pairs revealed a small, yet highly significant increase in pairwise correlations in R6/2 mice at all imaging time points (WT, 88580 cell pairs at 6.5 weeks, 114020 cell pairs at 7.5 weeks, 111645 cell pairs at 8.5 weeks, 91655 cell pairs at 9.5 weeks, from 6 mice; R6/2, 143716 cell pairs at 6.5 weeks, 164325 cell pairs at 7.5 weeks, 211011 cell pairs at 8.5 weeks, 222328 cell pairs at 9.5 weeks, from 5 mice; Wilcoxon rank-sum test, WT vs.

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