Ιmpact of sunitinib-induced hypothyroidism on survival of patients with metastatic renal cancer.

BMC Cancer · 2019 · PMC6492389 · PMID 31039771

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highly significantno p-value reported

A highly significant observation in our study is that the magnitude of TSH increase in the very early stages of treatment with sunitinib (day-15) appears to have a prognostic value.

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an increasing trendno p-value reported

In addition, during the last years, the incidence of kidney malignant tumours appears to have an increasing trend [ 2 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.