Baclofen but Not Diazepam Alleviates Alcohol-Seeking Behavior and Hypothalamic-Pituitary-Adrenal Axis Dysfunction in Stressed Withdrawn Mice.

In non-stressed animals, no significant between-group difference was observed [control 1W: 105.2 ± 9.9, withdrawn 1W: 124.8 ± 7.3, control 4W: 98.4 ± 7.8, and withdrawn 4W: 91.0 ± 10.6; F (3,31) = 2.62; p = 0.067]; in contrast, a highly significant between-group difference was observed in stressed mice [control 1W: 125.2 ± 11.6, withdrawn 1W: 103.6 ± 6.6, control 4W: 81.0 ± 7.75, and withdrawn 4W: 95.87 ± 12.4; F (3,31) = 7.35; p = 0.0007], even though withdrawn 1W and 4W mice did not differ significantly from their respective stressed control groups [ F (1,15) = 1.26 and F (1,16) = 2.31, respectively; p > 0.05 in both analyses; g = 0.72 and g = 0.84, respectively].

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