Global Spread of Mutant PfCRT and Its Pleiotropic Impact on Plasmodium falciparum Multidrug Resistance and Fitness.

In view of the highly significant association between the PfCRT mutations N326S and I356T and the emergence of ART resistance in SE Asia (with a P value of 7 × 10 −10 ) ( 20 ), we tested whether these mutations could individually or collectively influence antimalarial susceptibility and/or parasite fitness in a way that would explain their local dominance across SE Asia.

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