Despite the fact that the allele size thus determined shows a highly significant negative correlation with age of onset, this allele size explains less than 50% of the variation in age of onset [ 8 – 10 , 12 , 34 , 35 ].
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Analysis of mutational dynamics at the DMPK (CTG)n locus identifies saliva as a suitable DNA sample source for genetic analysis in myotonic dystrophy type 1.
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