Cardiometabolic risk factors in Thai individuals with prediabetes treated in a high-risk, prevention clinic: Unexpected relationship between high-density lipoprotein cholesterol and glycemia in men.

In multivariable linear regression analysis (Table 3 ) with adjustment for the individual characteristics of age, sex, BMI, waist circumference, possible NAFLD, male–FPG interaction, female–HbA1c interaction, antihypertensive drug or statin use and FPG or HbA1c, neither HbA1c nor FPG were independently associated with any of the cardiometabolic risk factors analyzed, including HDL cholesterol ( P = 0.6), but the negative interaction between female sex and HbA1c with respect to HDL cholesterol was still apparent, albeit at borderline significance (Table 3 ; coefficient: −0.02, 95% CI −0.05 to 0.003 mmol/L, P = 0.08), whereas the positive interaction between male sex and FPG with respect to HDL cholesterol was still fully significant (Table 3 ; coefficient: 0.21, 95% CI 0.05–0.37 mmol/L, P = 0.009).

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