Appropriate interactions that affect the expression of PTEN may be significant in the development of the disease.
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Molecular Mechanisms in Clear Cell Renal Cell Carcinoma: Role of miRNAs and Hypermethylated miRNA Genes in Crucial Oncogenic Pathways and Processes.
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For instance, the reduced expression of miR-124 is considered a highly significant factor in ccRCC genesis and may be an essential predictor of survival ( Butz et al., 2015 ).