Association between cumulative anticholinergic burden and falls and fractures in patients with overactive bladder: US-based retrospective cohort study.

48 A borderline significant association was reported between antimuscarinic use and fractures among Taiwanese patients with OAB, although assessment of anticholinergic burden was based on a single dispensation only. 49 That increased anticholinergic burden was associated with increased falls and fractures among those with OAB is consistent with findings from those with Parkinson’s disease, 5 depression 50 and among post-menopausal women. 4 Exact estimates of increased risk are difficult to compare directly because most studies measured burden cross-sectionally and not cumulatively.

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