Barely Significant
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Overtime trend of thyroid hormones and thyroid autoimmunity and ovarian reserve: a longitudinal population study with a 12-year follow up.

BMC Endocr Disord · 2019 · PMC6505305 · PMID 31064360

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a positive trendno p-value reported
Conclusion Women with the lowest ovarian reserves had higher levels of TPO Ab, with a positive trend of this antibody overtime in comparison to other quartiles, indicating that this group may be at a higher risk of hypothyroidism over time.

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