FunSPU: A versatile and adaptive multiple functional annotation-based association test of whole-genome sequencing data.

As for APOC4-APOC2 , three of the six annotations, namely, Funseq2, RegulomeDB and GenoSkyline ( S11E , S11H and S11I Fig ), positively contributed to the highly significant p -values of wtFunSPU and FunSPU ( S11A and S11B Fig ), although none of these individual annotation-based aSPU tests would reach the genome-wide significance threshold, demonstrating the benefit of integrating multiple functional annotations in the FunSPU framework.

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