A highly significant finding was the demonstration that Ca 2+ is involved in the binding and/or exchange of the slowly exchanging substrate water molecule (Hendry and Wydrzynski 2002 , 2003 ).
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A highly significant finding was the demonstration that Ca 2+ is involved in the binding and/or exchange of the slowly exchanging substrate water molecule (Hendry and Wydrzynski 2002 , 2003 ).