It may be significant that a Cas4-like protein is encoded in the genome of a phage that replicates in this Roizmanbacteria, given that a Cas4-like protein in a Campylobacter sp. phage was suggested to facilitate acquisition of self-targeting spacers into the CRISPR-Cas system of its host ( Hooton and Connerton, 2014 ).
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Candidate Phyla Radiation Roizmanbacteria From Hot Springs Have Novel and Unexpectedly Abundant CRISPR-Cas Systems.
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