The blood–brain barrier (BBB) is highly significant in terms of drug transport across the brain and is a very efficient barrier that is designed to filter molecules which may be harmful to brain function. 50 Intestinal absorption is an important factor for effective drug candidates and human intestinal absorption properties depend on the physiochemical properties of compounds. 51 Better ADMET profile analysis was seen in the case of lupeol as compared to iso-orientin.
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In silico and in vitro studies of lupeol and iso-orientin as potential antidiabetic agents in a rat model.
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