Barely Significant
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Loss of claudin-3 expression induces IL6/gp130/Stat3 signaling to promote colon cancer malignancy by hyperactivating Wnt/β-catenin signaling.

Oncogene · 2017 · PMC6512312 · PMID 28783170

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hedged sentence
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The sentences

highly significantp<0.001actually significant
However, this decrease was progressive as loss of claudin-3 in all stages of CRC ( versus normal mucosa) was highly significant (p<0.001) ( Fig-2A ).

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