Nontuberculous mycobacterium M. avium infection predisposes aged mice to cardiac abnormalities and inflammation.

avium dissemination in old mice upregulates canonical pathways related to immune cell recruitment, inflammation, fibrosis, and cell death Using Ingenuity Pathway Analysis (IPA), we examined the relationship between these differentially expressed and highly significant genes (230 genes) to determine the most significant canonical pathways and biological networks involved in M. avium infected old mice hearts (Table 1 ).

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