Endothelin-1 Induces Mesothelial Mesenchymal Transition and Correlates with Pleural Fibrosis in Tuberculous Pleural Effusions.

J Clin Med · 2019 · PMC6517891 · PMID 30925731

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a favorable trendno p-value reported

As for the therapeutic implication of ET-1 for pleural fibrosis, previous reports have demonstrated that ET receptor antagonist treatment efficiently attenuated ET-1–mediated alveolar EMT in vitro [ 5 , 6 ], mitigated bleomycin-induced lung fibrosis in vivo [ 27 ], and displayed a favorable trend to improve progression free survival of histology–proven IPF patients [ 28 , 29 ].

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