Effectiveness and Safety of Direct Oral Anticoagulants versus Vitamin K Antagonists for People Aged 75 Years and over with Atrial Fibrillation: A Systematic Review and Meta-Analyses of Observational Studies.

J Clin Med · 2019 · PMC6518135 · PMID 31022899

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of borderline significanceno p-value reported

Outcomes Overall, the pooled risk estimate for both ischaemic stroke and composite effectiveness outcomes were of borderline significance (ischaemic stroke: seven studies, 0.86 (95% CI 0.75–0.99), Figure 2 ; composite effectiveness outcomes: nine studies, 0.93 (95% CI 0.85–1.01), Figure 3 ) between DOACs and VKA.

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