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Circulating sphingosine-1-phosphate as a prognostic biomarker for community-acquired pneumonia.

PLoS One · 2019 · PMC6519827 · PMID 31091284

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an increasing trendno p-value reported
In contrast, an increasing trend of the S1P level was noted in a panel of COPD patients with pneumonia (N = 30), suggesting selective upregulation of S1P in pneumonia cases.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.