Genomic structural equation modelling provides insights into the multivariate genetic architecture of complex traits.

Nat Hum Behav · 2019 · PMC6520146 · PMID 30962613

Europe PMC DOI

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suggestive of significancep < 1 × 10 −5actually significant

Of these 27 loci, five loci were identified as either genome-wide significant or suggestive of significance ( p < 1 × 10 −5 ) in a separate, previously published GWAS of one of the five traits. 118 loci were genome-wide significant for neuroticism, with 38 loci not identified in the univariate item-level GWASs ( Supplementary Table 6 ; Figure 1b , Figure 2b ).

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highly significantp < .001actually significant

Results indicated highly significant loadings, and a small correlation between the two factors ( r g = .10, SE = .03, p < .001).

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