Association of Selenoprotein and Selenium Pathway Genotypes with Risk of Colorectal Cancer and Interaction with Selenium Status.

For pathway 1, the TXNRD1 selenoprotein variant rs11111979, an intron 3′–5′UTR SNP previously associated with healthy aging [ 35 ], remained borderline significant for an association with CRC risk ( P ACT = 0.100; P ACT significance threshold was P < 0.1) in the recessive genetic model.

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However, for pathway 1 only the TXNRD1 selenoprotein gene rs11111979 SNP retained borderline significance after correction for multiple testing.

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