In total, 488 analyzed features, which encompasses total production, strain contributions, and reaction abundances, were significantly different ( p -value <0.05), of which 375 were highly significant ( p -value <0.001) (Additional file 1 : Table S7).
Primary bile acid deconjugation potential was lower in IBD patients but only borderline significant after adjustment for FDR (adjusted p value = 0.0551); however, the abundance of the bile salt hydrolase reaction was significantly reduced in IBD microbiomes ( p value 0.0235, Additional file 1 : Table S7) and also differed based on phylum-and genus-level reaction abundances for many taxa (Additional file 1 : Table S7).