almost significantlyp = 0.051
At 13 months, the concentration of the downstream metabolite 7αH,3O-CA was almost significantly different ( p = 0.051, Supplementary Materials , Figure S8 ) between the wt (25.89 ± 10.91 ng/mL) and the Cyp7b1-/- mice (14.21 ± 3.76 ng/mL) [ 12 ]. 7α,12α-Dihydroxycholesterol (7α,12α-diHC) and 7α,12α-dihydroxycholest-4-en-3-one (7α,12α-diHCO) are observed in plasma of both genotypes.