Single-Cell RNA-Sequencing-Based CRISPRi Screening Resolves Molecular Drivers of Early Human Endoderm Development.

Despite low statistical power for measuring individual transcripts in scRNA-seq, guides display an overall trend toward knockdown ( Figure S2G ), with 75% of gRNAs knocking down their target (uncorrected p < 0.05, log FC < 0; Table S3 ), which is comparable to the results previously described ( Dixit et al., 2016 ).

also in 4,871 other papers