Recent advances in <i>Staphylococcus aureus</i> infection: focus on vaccine development.

43 , 44 However, in a recent observational study on pediatric clinical cultures performed between 2005 and 2017 in the United States, a declining trend of MRSA from 41% to 27% over the study period, yet an increasing trend of clindamycin (from 21%–38% in MRSA and 5%–40% in MSSA) and trimethoprim-sulfamethoxazole (from 2%–13% in MRSA and relatively stable in MSSA) resistance were reported. 45 Moreover, other studies have reported an increased incidence of MRSA as well as antibiotic resistance. 46 – 49 Multiple factors

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