A Large-Scale Genome-Wide Association Study in U.S. Holstein Cattle.

The 1.19–7.98 Mb region of Chr14 had two unique features: the extremely significant effects of rs109421300 in DGAT1 at 1,801,116 bp, which is 1,153 bp upstream of the K232A causal mutation (Grisart et al., 2004 ), and the large cluster of highly significant effects ( Figure 2A ).

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These methods virtually identified the same set of highly significant additive effects with minor differences in the rankings of statistical significance ( Tables 1 – 4 ) although the differences in effect ranking between these two methods became larger for less significant SNP effects ( Table S5 ; Figure S3 ).

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