Barely Significant
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The impact of acute thermal stress on the metabolome of the black rockfish (Sebastes schlegelii).

PLoS One · 2019 · PMC6534312 · PMID 31125355

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an increasing trendno p-value reported
However, only brain tissue was observed to have an increasing trend in the expression of HIF2α in response to acute high thermal stress, which indicated that different types of HIF-αs have different functions.

also in 63,971 other papers

extremely significantno p-value reported
Notably, liver ub gene expression in the 27°C group had an extremely significant increase in contrast to that in the 16°C group while expression in the 5°C group significantly decreased (P < 0.01).

also in 7,787 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.