Modulation of Coenzyme Q<sub>10</sub> content and oxidative status in human dermal fibroblasts using HMG-CoA reductase inhibitor over a broad range of concentrations. From mitohormesis to mitochondrial dysfunction and accelerated aging.

Aging (Albany NY) · 2019 · PMC6535058 · PMID 31076563

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highly significantno p-value reported

As a consequence, in the high range of statin exposure, we observed a highly significant increase in mitochondrial superoxide anion production as well as an accumulation of cellular ROS.

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