Optimisation of a screening platform for determining IL-6 inflammatory signalling in the senescence-associated secretory phenotype (SASP).

Having established that the HEK-SASP assay could measure inflammatory signalling in vitro at IL-6 concentrations relevant to those found in the SASP, we were able to demonstrate that inflammatory signalling increases with cellular population age (CPD), with a highly significant increase in detected IL-6 as cells near senescence (Fig. 3 c).

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