There is also highly significant increase in the fraction of cells with negative staining for prelamin A (71%) compared to the untreated HGPS fibroblast cells (23%), bringing the overall results for rapamycin treatment with respect to prelamin A in line with those of the control fibroblasts.
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Presence and distribution of progerin in HGPS cells is ameliorated by drugs that impact on the mevalonate and mTOR pathways.
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